Young people are an important and valuable stakeholder in addressing the global health threat of AMR since they are the next generation of public health professionals; the potential future antimicrobial prescribers, users, stewards, and policymakers in their professional practice. The Africa Tertiary Students’ AMR leaders program seeks to empower tertiary students from Africa. By equipping them with the relevant skills, strengthening their capacity and offering them support, these students can lead student’s initiatives in their respective countries and empower other students to engage in AMR through the Training the Trainer (ToT) approach. The actions can be diverse such as facilitating active engagements on AMR in One Health clubs, partnering with other students to engage in research, and developing innovative solutions that can help mitigate AMR among Other Activities. The program has tertiary students from different countries and in different levels of learning.